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Version du 27 mars 2021 à 01:33
In elastase-handled rats, cigarette smoke from excessive-dose nicotine-containing cigarettes does induce extra emphysematous changes than smoke from low-dose nicotine cigarettes . Several animal research have demonstrated that nicotine exposure alone may induce pathogenic responses similar to those that happen in COPD. Intranasal administration of nicotine in mice resulted in impaired autophagy, enhanced oxidative stress and bronchial epithelial cell apoptosis .
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